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Positive hepatitis B surface antigen tests due to current vaccination a problem that is persistent

Positive hepatitis B surface antigen tests due to current vaccination a problem that is persistent


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Hepatitis B virus (HBV) is a very common reason behind viral hepatitis with significant health problems including cirrhosis and carcinoma that is hepatocellular. Assays for hepatitis B surface antigen (HBsAg) are the absolute most commonly used tests to detect HBV infection. Vaccination for HBV can produce transiently detectable quantities of HBsAg in patients. Nonetheless, the time program and duration of the impact is uncertain. The objective of this retrospective study had been to make clear the regularity and duration of transient HBsAg positivity following vaccination against HBV.


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The electronic medical record at an academic tertiary care medical center was searched to identify all sales for HBsAg inside a 17 month time period. Detailed chart review ended up being performed to determine all clients who were administered HBV vaccine within 180 days ahead of HBsAg screening and also to ascertain cause that is likely of g d (grayzone) outcomes.


Throughout the 17 study period, 11,719 HBsAg tests were ordered on 9,930 patients month. There were 34 tests performed on 34 patients whom received HBV vaccine fortnight or less ahead of HBsAg assessment. Of those 34 clients, 11 had grayzone results for HBsAg that might be related to present vaccination. Ten associated with 11 clients were renal dialysis clients who had been getting HBsAg screening included in routine and ongoing monitoring. Beyond 2 weeks, there have been no reactive or grayzone HBsAg tests that would be related to recent HBV vaccination. HBsAg results reached a peak COI two to three days vaccination that is following decaying. Further analysis of all grayzone results in the 17 study period (43 results out of 11,719 tests) revealed that only 4 of 43 were the result of true HBV infection as verified by confirmatory testing month.